O'Keeffe's Working Hands Night Treatment – Hypoallergenic Hand Cream for Sensitive, Diabetic Skin, 7 oz
O'Keeffe's Working Hands Night Treatment – Hypoallergenic Hand Cream for Sensitive, Diabetic Skin, 7 oz
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Why you'll love it
- Visible improvement in as little as one night delivers fast, tangible payoff over regular lotions
- Trusted #1 hand cream brand in America reduces risk for first-time buyers
- Non-greasy finish means it can be applied right before bed without ruining sheets or pajamas
- Hypoallergenic, unscented, and diabetic-safe formula removes worry for sensitive or medically vulnerable skin
- Overnight passive treatment fits into existing bedtime routine without adding daytime hassle
- Larger 7 oz tube and multi-pack options offer better per-ounce value for chronic sufferers
Perfect for
- Overnight restorative treatment applied at bedtime to repair cracked hands by morning
- Post-handwashing moisture seal applied in the bathroom after sanitizing or washing
- After-bath or shower hand care to lock in hydration when skin is most receptive
- Long-term maintenance for diabetes-related or age-related extreme hand dryness
- Stocking multiple bathrooms or sinks via 7 oz twin-pack bulk supply
Product Information
Get your hands back overnight: O’Keeffe’s Working Hands Night Treatment is a calming yet intense, restorative hand cream for cracked, dry hands that works while you sleep; From the #1 hand cream brand in America*
Dry hands nighttime remedy: O'Keeffe's Night Treatment Cream for extremely dry hands is a calming yet intense, restorative hand cream that relieves extremely dry, cracked hands while you sleep; Shows visible improvements in as little as one night
Made with deep conditioning oils: Our Night Treatment formula leaves your hands feeling soothed and moisturized overnight without leaving any greasy feeling behind
Recommended use: For best results, apply after hand washing, after bathing, and at bedtime - these are the most effective times for moisturizing extremely dry hands and skin
Hypoallergenic: O'Keeffe's Working Hands is unscented, non-greasy and safe for people with diabetes; Our 7 ounce tube is perfect for a reliable at-home supply of comfort and moisture
O’Keeffe’s Working Hands Night Treatment hand lotion for dry hands is a calming yet intense, restorative hand cream that is designed to instantly relieve extremely chapped, dry hands while you sleep. O'Keeffe's Working Hands Night Treatment contains natural grapefruit and lavender oil while being hypoallergenic. Made with deep conditioning oils. This formula won't leave a greasy feel on your hands after you use it. O'Keeffe's Night treatment locks in moisture and works while you sleep. See visible results to your hands in at as little as one night.
Items Details
Frequently Asked Questions
Is this formula safe for people with diabetes?
Yes, it is specifically formulated as diabetic-safe, hypoallergenic, and unscented, so it is suitable for people with diabetes or other medically sensitive skin conditions.
Will the lavender and grapefruit oils cause skin reactions?
The natural oils are used at low concentrations within a hypoallergenic base, and the finished product is unscented, so it is generally well tolerated even by people with fragrance sensitivities.
Can I use this if I have eczema or extremely reactive skin?
The hypoallergenic, fragrance-free formula is designed for sensitive skin, and many users with eczema report it as one of the few hand creams that does not sting or trigger flare-ups, though you should always patch test first.
Is it safe to use every single night long-term?
Yes, the formula is designed for nightly use as an ongoing treatment, and there are no harsh active ingredients, exfoliants, or steroids that would cause concern with extended daily application.
Will this irritate cuts, cracks, or open wounds on my hands?
The cream is gentle enough to apply over cracked skin without stinging, and many users apply it directly onto fissures and find it soothing, but deep open wounds should be treated by a healthcare professional first.
Is this safe to use around children or pets in the household?
Yes, the unscented, non-greasy, topical hand cream poses no inhalation or fire risk, and because it absorbs fully, there is no residue for curious children or pets to lick off your hands after application.
Does this contain any parabens, phthalates, or harsh preservatives?
The formula is built around a deep conditioning oil base with natural grapefruit and lavender oils, and it is designed to be hypoallergenic, so it avoids the most common irritants found in regular lotions.
Can a healthcare worker or nurse safely use this between shifts?
Yes, the diabetic-safe, hypoallergenic formula is appropriate for healthcare workers who wash and sanitize dozens of times per day, and the non-greasy finish means it does not interfere with glove use.
Is this safer for my skin than using steroid creams for cracked hands?
It is a non-prescription moisturizing treatment without steroids, so it can be used nightly as a first-line approach before resorting to medicated creams, though you should consult a doctor for severe or persistent conditions.
Will the 7 oz squeeze tube stay sealed and hygienic over time?
Yes, the tube has a secure flip cap that keeps the product sealed from bathroom humidity, dust, and contamination, so it stays hygienic from first squeeze to last.
How does this compare to antibiotic ointments for cracked skin?
Antibiotic ointments treat infection but do not moisturize, whereas this is a deep conditioning treatment that repairs the skin barrier itself, making it a better long-term preventive solution for recurring cracks.
Is this safer than homemade remedies like coconut oil or shea butter?
Yes, this product is formulated, tested, and stabilized for consistent results, whereas homemade oils can vary in quality, oxidize quickly, and may trap bacteria against the skin rather than repairing the barrier.
What if I have a nut allergy, is this safe to use?
The formula is built around a conditioning oil base and natural plant oils, but if you have specific nut or plant allergies, review the full ingredient list on the package or consult your allergist before first use.
Can I use this if I am pregnant or breastfeeding?
The unscented, hypoallergenic topical formula is generally considered safe during pregnancy and breastfeeding, but as with any skincare product, you should consult your OB-GYN or midwife if you have concerns.
How do I use O'Keeffe's Working Hands Night Treatment for best results?
Apply a small amount to clean, dry hands as the last step of your evening routine, massaging it into the knuckles, cuticles, and any cracked areas, then leave it on overnight while you sleep so the time-release formula can repair the skin barrier by morning.
Can I use this cream during the day as well, or only at night?
You can use it any time, but it is specifically formulated as an overnight treatment with deep conditioning oils, so applying it at bedtime gives it several uninterrupted hours to work without being washed or wiped off.
How long does one 7 oz tube last with nightly use?
A 7 oz tube used once per night typically lasts about two to three months, and the twin-pack stretches that further for chronic users or shared bathrooms.
Is this hand cream compatible with cotton sleep gloves or overnight gloves?
Yes, it works very well under cotton gloves for an enhanced deep-conditioning treatment, and because the finish is non-greasy, you can also sleep without gloves and still get full repair benefits.
Will this tube fit in a standard bathroom holder, purse, or travel bag?
The 7 oz tube is slim enough for most bathroom cup holders, and the 3 oz travel pack of 2 is designed specifically for purses, gym bags, and carry-on luggage.
What is included in the box when I order this product?
Depending on the variant you select, you receive either a single 7 oz squeeze tube, a 7 oz twin-pack, or a 3 oz travel pack of 2 tubes, all with secure flip caps and ready to use immediately with no additional setup.
Is this product tested on animals or made with animal-derived ingredients?
O'Keeffe's is a trusted American brand focused on effective, sensitive-skin-friendly formulations, and you should review the current packaging or brand site for the most up-to-date information on cruelty-free status and ingredient sourcing.
How should I store the tube to keep it from drying out or going bad?
Store it at room temperature with the cap firmly closed, away from direct sunlight and extreme heat, and it will stay fresh and effective for the full life of the tube.
What is the difference between a hand cream and a hand lotion?
Hand lotions are typically lighter, water-based products designed for quick daytime moisturizing, while hand creams like this one are richer, oil-based treatments built for deep, long-lasting repair of cracked, dry, or compromised skin.
