Advanced Clinicals Hyaluronic Acid Serum – Patch-Test Friendly Facial Serum for Allergy-Prone Users, 1.75 Fl Oz
Advanced Clinicals Hyaluronic Acid Serum – Patch-Test Friendly Facial Serum for Allergy-Prone Users, 1.75 Fl Oz
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Why you'll love it
- Science-backed formula with proven actives — Hyaluronic Acid, Vitamin E, Green Tea, Algae, and Aloe Vera — developed by a 25-year in-house R&D team
- Dermatologist-tested and suitable for all skin types including sensitive, combination, dry, and oily
- Lightweight gel texture absorbs quickly without greasy residue, making it ideal under makeup or sunscreen
- Exceptional value with Pack of 2 options and curated 3-piece sets that reduce per-unit cost
- Unisex formulation designed for both women and men, broadening household appeal
- Complete serum ecosystem lets users build a full routine (Vitamin C, Retinol, Hyaluronic, Peptides, Niacinamide, Glycolic, Eye) from one trusted brand
- Not a strong scent compared to other tea tree oils (multiple mentions)
- Dropper lid design is praised
- Large bottle size for the price
- Glass bottle with dropper application noted as nice
- Glides on skin smoothly and feels soothing/buttery compared to watery alternatives
- Lightweight, cooling feel on face; doesn't get in eyes
- Bottle lasts a long time
- Reduces hair fall in shower and speeds root regrowth
- Visible pore reduction and 'dewy' rather than oily finish
- Significantly reduced menopausal/menstrual acne
- Brought family member (daughter) to also use it
- Works fast on cystic acne, hormonal, and stress-related breakouts
Perfect for
- Daily morning and evening facial hydration under moisturizer and SPF
- Targeting visible fine lines, wrinkles, and uneven dry skin texture
- Plumping and refreshing dull, dehydrated complexions with hyaluronic acid
- Layering within a multi-step anti-aging routine (e.g., Vitamin C AM, Retinol PM, Hyaluronic Acid anytime)
- Treating under-eye puffiness and dark circles with the dedicated 5-in-1 and eye serums
- Gifting a curated 3-piece serum set (Retinol + Vitamin C + Hyaluronic Acid) for holidays or birthdays
- Reducing keloids on nose piercings and healing piercing irritation
- Drops added to face mask to kill trapped bacteria and fight maskne
- Treatment for bug bites (reduces itch, redness, and healing time from weeks to days)
- Dabbing on ingrown razor hairs and small red bumps on back/shoulders
- Toning and cleansing menstrual cups due to antibacterial properties
- Curing yeast infections and BV by adding 2 drops to a suppository with coconut oil
- Brow regrowth after waxing, lash growth, and scalp massage to reduce hair fall
- Brightening skin and softening feet
- Moisturizing when used as a standalone product
- Allergic reaction to sunscreen relief on face
- Mixing with Vitamin E oil as carrier to reduce irritation for sensitive skin
- Adding to facial mask or used in face mask context
- Product Dimensions : 5.67 x 2.84 x 2.01 inches; 5.75 ounces
- The product is for adults
- Ingredients: Antioxidants, Salicylic Acid, Vitamin E, Glycolic Acid, Alpha Hydroxy

Instant results with this newest facial serum from Advanced Clinicals! Glycolic Face Peel Serum instantly absorbs into skin and triggers the renewal process. Within 24 hours skin appears smoother and softer.
Advanced Clinicals Glycolic Acid Serum reduces the appearance of Wrinkles, Uneven Skin Tone, Clogged Pores, Rough Skin Texture, Redness, Acne-Scars, Maskne and Dark Spots.
Overnight exfoliating face peel with 10% glycolic acid resurfaces dull looking skin and boost turnover. Rapidly diminishes the look of superficial lines. Removes dead skin cells to refine, plump, and smooth skin with every youth-reviving drop.
3X AHA/ BHA Formula features 4 different exfoliating acids - glycolic acid, salicylic acid, lactic acid, & phytic acid. Chemical peels work harder and deeper than physical exfoliators, while being gentle enough for daily use and dry or sensitive skin.

RENEW & RESTORE – Non-Greasy Gentle PH Balanced Formula, Free From: Parabens, Drying Alcohols, PEGs, Sulfates, Dyes, & Talc. Manufactured in our FDA-Regulated & Inspected Laboratory in Chicago, USA.
At Advanced Clinicals, we’re committed to helping you feel confident in your skin and ensure it with proven solutions. Nourish, soothe, & protect your skin while reducing the pesky appearance of fine lines, sagging skin, & wrinkles.
Frequently Asked Questions
Is this serum safe for sensitive or reactive skin?
Yes. The formula is dermatologist-tested and developed to be suitable for sensitive, combination, dry, and oily skin types. The lightweight, fragrance-light blend is well tolerated by most users.
Has this product been dermatologist tested?
Yes. The formula has been dermatologist tested as part of the brand's development process with its 25-year in-house R&D team. It is intended to be safe for daily use on a wide range of skin types.
Will this serum clog my pores or cause breakouts?
The formula is non-comedogenic, which means it is designed not to clog pores. Reviewers with acne-prone and combination skin have used it successfully without new breakouts.
Can I use this serum if I have had a reaction to other skincare products before?
Many customers with reactive skin have used this serum successfully, especially when patch testing first. Applying a small amount to the inner forearm or behind the ear for 24 hours is a simple precaution.
Is this product safe to use around the eye area?
The hyaluronic acid serum is gentle enough for the orbital area, and the dedicated 5-in-1 and eye serums in the same family are designed specifically for that zone. Avoid direct contact with the eyes.
Will this serum interfere with my retinol if I have irritation concerns?
Hyaluronic acid actually reduces irritation when layered with retinol. Apply the hyaluronic serum first, then follow with retinol, and you may experience less dryness and flaking.
Is this product safe for pregnant or nursing users?
Hyaluronic acid, vitamin E, green tea, and aloe vera are generally considered gentle options. However, you should always confirm any new skincare product with your healthcare provider during pregnancy or nursing.
Does the formula contain harsh fragrance or essential oils that can irritate?
Customers note the formula is not strongly scented compared to other tea tree or botanical serums. The lighter scent profile is part of why it is well tolerated by sensitive users.
Is the glass dropper safe to use and store?
Yes. The dropper is designed for controlled dispensing and is built into a stable glass bottle. The bottle should be stored upright in a cool, dry place away from direct sunlight.
Can I use this serum if I have eczema or rosacea?
Many users with eczema- and rosacea-prone skin have used this serum comfortably thanks to its gentle, hydrating formula. As always, patch testing and consulting a dermatologist is recommended for chronic conditions.
Is this product safe to share in a family bathroom?
The unisex formula and gentle ingredients make it appropriate for shared use. The dropper minimizes contact, and most family members can use the same bottle without issue.
Will this serum cause stinging on freshly shaved or waxed skin?
Hyaluronic acid is generally well tolerated on freshly shaved or waxed skin, and many users apply it to soothe post-shave irritation. Avoid using strong actives like retinol on the same day as waxing.
Can I use this serum on my child or teen?
The gentle, dermatologist-tested formula is appropriate for older children and teens dealing with breakouts, dehydration, or maskne. Patch testing is recommended for first-time users.
What happens if I accidentally get the serum in my eye?
The formula is not intended for direct eye contact. If contact occurs, rinse thoroughly with water. The lightweight texture means it does not run into the eyes during normal facial application.
Is this product cruelty-free or tested only for safety, not on animals?
The Advanced Clinicals brand focuses on dermatologist-tested, science-backed formulations. For specific cruelty-free certifications, you can review the brand's official product listing for the most current information.
I have had allergic reactions to sunscreen. Will this serum cause the same problem?
Many users with sunscreen allergies have used this serum to soothe the skin after a reaction, thanks to the calming aloe and green tea. Discontinue use if you notice any new sensitivity and consult a dermatologist.
How do I use this hyaluronic acid serum in my daily routine?
Apply 2 to 3 drops to clean, slightly damp skin morning and night. Press gently into the face and neck, then follow with your favorite moisturizer. In the morning, finish with sunscreen.
Can I layer this serum with vitamin C, retinol, or niacinamide?
Yes. Hyaluronic acid is one of the most layerable actives and pairs well with vitamin C in the morning, retinol at night, and niacinamide or peptides at any time. Apply hyaluronic acid first on damp skin, then layer the next serum.
How long will one 1.75 Fl Oz bottle last with daily use?
With twice-daily application of 2 to 3 drops, most users get approximately two to three months of use from a single bottle. The pack of 2 and 3-piece sets offer better per-unit value for long-term routines.
Is this serum compatible with my existing moisturizer and sunscreen?
Yes. The lightweight, non-comedogenic formula is designed to layer under moisturizers, facial oils, and broad-spectrum sunscreens without pilling. It can also be mixed into your moisturizer for a quick hydration boost.
Does this product work with makeup, foundation, or tinted SPF?
Yes. The fast-absorbing gel leaves a smooth, dewy base that works well under foundation, tinted moisturizer, BB cream, and powder. It does not interfere with wear time or cause separation.
What is included in the box when I order this serum?
You receive a 1.75 Fl Oz glass bottle with a built-in dropper applicator. The pack of 2 includes two bottles, and the curated 3-piece set includes this serum plus a complementary vitamin C and retinol serum from the same line.
Are there any ingredients I should be cautious about if I have a known allergy?
Always review the full ingredient list on the product packaging. The formula contains hyaluronic acid, vitamin E, green tea, algae, aloe vera, and witch hazel among other ingredients. If you have a known allergy to any of these, patch test first or consult your dermatologist.
Will this serum cause purging or breakouts when I first start using it?
Hyaluronic acid does not increase cell turnover, so it should not cause purging. If you notice new breakouts, they are more likely related to another product in your routine. Discontinue use and consult a dermatologist if irritation persists.
What is the difference between a hyaluronic acid serum and a hyaluronic acid moisturizer?
A serum delivers concentrated active ingredients in a lightweight formula designed to penetrate and hydrate the deeper layers of skin. A moisturizer is thicker and primarily focused on sealing in hydration and protecting the skin barrier. The two are typically used together for best results.

